Immunohistochemical stainings were done to analyse the distribution of p53 and Rb proteins with various gastric epithelial lesions : normal, intestinal metaplasia, low grade and high gdrade gastric dysplasia, and gastric carcinoma. Normal and
intestinal
metaplastic epithelium revealed weak positivity for both p53 Rb proteins. Low grade gastric dysplasia was also diffusedly and mildly positive for two proteins. In contrast, in the area of high grade dysplasia, dysplastic cells were strongly
positive in
nuclei as well as in cytoplasm. Intranuclear strong immunostaining was persistant in gastric carcinomas regardless of histologic differences. It can be assumed that either p53 or Rb proteins may be involved in a spectrum of gastric epithelial
changes
directly or indirectly. Immunostaining for mutated p53 proteins may be used to determine the degree of gastric dysplasia in association with light microscopic features.
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